BIOL-391 Structures Behind Signaling

BIOL-391 Structures Behind Signaling

Costanzi, Stefano

The course focuses on the molecular mechanisms of signal transduction. In particular, we will review structure-function relationships of G protein-coupled receptors (GPCRs) and the proteins involved in the multitude of pathways through which they signal. We will also review signaling through receptors with associated tyrosine kinase activity and regulation of gene expression by intracellular nuclear hormone receptors (NHRs). Particular attention will be given to bibliographic searches and to the direct study of the pertinent literature. Each theoretical lecture will be followed by one hour of molecular modeling laboratory, in which we will visualize and analyze the three-dimensional structures of the studied signal transduction components. We will also generate homology models, analyze binding interfaces, and conduct computational ligand-protein and protein-protein docking experiments.

Credits: 3

Prerequisites: BIOL-151 or with special permission of the instructor

Other academic years
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• 2008-2009

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