NSCI-558 Molecular Mechanisms of Neurodegeneration
Fall for 2016-2017
This course examines the molecular basis of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease and Lou Gehrig's disease. The course includes discussion of mutations that cause familial forms of these diseases, and what these familial forms tell us about the sporadic forms. We examine how the genetic findings correlate with the neuropathological lesions identified in these diseases, and explore how these correlate with clinical symptoms. Classes include lectures on the background of biochemical mechanisms that lead to cell loss and discussions of recent papers chosen by students. The classes probe commonalities of the neurodegenerative diseases, selective vulnerability of subsets of neurons, genetic risk factors, and the usefulness and limitations of animal models.
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