TBIO-560 Animal Models of Cancer
Fall for 2017-2018
Spring for 2017-2018
Animal models are an invaluable tool for cancer research and the goal of TBIO 560 is to introduce graduate students to the wide variety of models available, to the factors that inform the choice of an appropriate model for the research planned, and to provide basic training in the ethical, legal, and technical aspects of their use. Carcinogen induced tumor models, immune compromised mouse / xenograft systems and the use of animals in ADME testing are discussed in depth and a major focus of the course is the design and use of transgenic and induced mutant mouse models, particularly systems that allow temporal and special control of gene expression or genetic modification. Special emphasis is given to the use of various small animal imaging modalities such as PET, CT, SPECT, Ultrasound, MRI, Bioluminescence, Fluorescence and their application in the serial analysis of live animals. The need for the use of appropriate statistical tools in the planning and analysis of animal studies is also stressed throughout the course. Students are evaluated by a final paper in which, having been provided with mock preliminary data, they are expected to explain, justify and design animal experiments to answer focused research questions, described in the format of the final aim of an R01 grant.
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